HAIR THERAPY @ CALECIM AHS
CALECIM® Professional Advanced Hair System (AHS) is a stem cell-derived serum containing key proteins and growth factors to help stimulate, nourish and condition the appearance of weak and struggling hair follicles. When infused into the scalp with a derma stamp or micro needling device, these powerful proteins are more likely to provide hair follicle support and visibly condition the skin on the scalp.
Calecim Advanced Hair System (AHS) treats both male and female pattern hair loss using a Mesenchymal stem cell growth factor serum that contains multiple growth factors and cytokines.
These include including Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Transforming Growth Factor (TGF), Insulinlike Growth Factor (IGF) and Hepatocyte Growth Factor (HGF).
In vitro results showed a cell growth of 24.1% with CALECIM® Professional Advanced Hair System (AHS), when compared to a dermal papilla cell growth of 24.5% with use of Minoxidil at a concentration of 2ug/ml, making this a good drug-free option.
These growth factors promote hair growth by acting on the hair follicle to increase blood supply and activity of hair growth, prolong the hair growth phase and encourages conversion from dormant to active hair follicles.
This treatment primarily addresses hair loss due to androgenetic alopecia and a proper diagnosis must be made to exclude other alternative causes of hair loss.
The recommended treatment protocol involves weekly treatments with CALECIM® Professional Advanced Hair System (AHS) for 6-12 sessions, depending on hair loss severity, in conjunction with scalp micro needling and Low Level Laser Therapy. In addition, topical minoxidil 5% and hair growth supplements shall also be recommended.
Results are typically seen in 3-4 months, with patients experiencing improved hair density and volume with less hair fall.
HAIR THERAPY @ EXOSOME
Exosome Stem Cell Therapy is a hair regrowth treatment with rising popularity that uses exosomes to stimulate hair growth.
Exosomes are extracellular vesicles that are produced by mesenchymal stem cells which are involved in cell communication. Other cells react to the messaging signals from the exosomes and will change their behavior accordingly. Scientists are now able to isolate and deliver these beneficial signalers directly rather than the stem cells themselves.
By injecting exosomes and growth factors, it has been clinically shown to help regenerate and regrow hair as a treatment for hair loss in both men and women in the earlier stages of hair loss.
When used on hair, exosomes from follicular stem cells can:
Inhibit cell ageing
Relieves inflammation to help improve scalp
Promote regenerative wound healing
Improve problematic scalp environment
Stimulates dermal papilla cells cell proliferation that help in hair growth
Strengthen hair roots
Promotes cytokines involved in hair growth
These altogether restore the hair environment, promoting hair growth. They promote cellular growth and inherit several useful growth factors, including those that:
Recruit mononuclear cells (mixture of different types of cells)
Encourage blood vessel formation
Encourage stem cell and melanocyte growth
Convert inflammatory cells to anti-inflammatory cells
Most notably, exosomes prolong the hair growth cycle by converting hair follicles stuck in the telogen phase to the anagen phase.
What are Exosomes?
Exosomes are stem cells per say. Instead, they are the building blocks of such. They generate within their cells of origin if the multivesicular body fuses with the cell membrane, thereby releasing intraluminal vesicles as exosomes. These small cellular products contain both RNA and, even of greater import, mRNA; the initiator of protein manufacturing.
These protein building blocks' roles are dependent on their cell of origin. Many act as signalers for bodily functions, such as coagulation, as well as cellular growth to facilitate said bodily functions. Such signaling and growth factors, studies currently show, are a result of the exosome's origin. Near all, however, have a number of useful growth factors/signalers:
MIP-1: A recruiter of mononuclear cells
VEGF: A stimulator to encourage blood vessel formation
SCF: An encourager of stem cell and melanocyte growth
FGF: A growth factor that signals cells to encourage biological development
TGFß3: A gene variant that, among other things, converts inflammatory T Cells into anti-inflammatory T-Cells
Exomes are core substances that transmit messages between cells in the human body. Think of them as avatars for stem cells; they possess the regenerative effects of a stem cell and deliver stem cell efficacies to receptor cells.
Exosomes are isolated from donated human amniotic mesenchymal stem cells and purified using proprietary processing. The unique benefit of these exosomes is that they are stem cell-derived and bring a wide array of growth factors. Because they’re so small and nimble, exosomes can remain hidden in the bloodstream, and carry multiple doses of proteins across barriers that cells are not able to cross.
Research into exosomes is happening for a number of purposes; male and female sexual functioning/revitalization, joint regeneration, and facials. Studies into their viability for biomarkers, Lyme disease treatments, and rheumatoid arthritis (RA) are also being looked into. Exosomes from follicular stem cells, the logic goes, facilitate hair growth and can help prevent hair loss.